LM-030
LM-030 (BPR277) is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC50s of 6 nM and 55 nM, respectively (Example 4) [1]. LM-030 can be used for the study of Netherton syndrome[2].
Product Specifications
CAS Number
1122484-55-2
Product Name Alternative
BPR277
UNSPSC
12352209
Target
Elastase
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lm-030.html
Solubility
10 mM in DMSO
Smiles
CC[C@@H]([C@]1([H])N2C([C@@](CC[C@H]2O)([H])NC([C@@H](NC([C@H]([C@H](OC([C@](NC([C@@H](N(C1=O)C)CC3=CC=C(C=C3)O)=O)([H])[C@@H](C)CC)=O)C)NC([C@H](CCC(N)=O)NC(C(C)C)=O)=O)=O)CC(C)C)=O)=O)C
Molecular Formula
C46H72N8O12
Molecular Weight
929.11
References & Citations
[1]Philipp Krastel, et al. Cyclic depsipeptides. WO2009024527A1|[2]Evgeniya Petrova, et al. Advances in understanding of Netherton syndrome and therapeutic implications. Expert Opinion on Orphan Drugs. 29 Dec 2020.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
RAC23214-01 100 mg
6-Fluoro-2,3-dihydro-1-benzofuran-3-amine hydrochloride
Sign In for Pricing
View Details RAC23214-02 1 g
6-Fluoro-2,3-dihydro-1-benzofuran-3-amine hydrochloride
Sign In for Pricing
View Details 
GTR15174237 1 Vial
Lentiviral mouse Fpr3 shRNA (UAS) - Lentiviral mouse Fpr3 shRNA (UAS, GFP) (100)
Sign In for Pricing
View Details GTR15364963 1 Vial
Lentiviral human SNRPC sgRNA gene knockout kit - Lentiviral human SNRPC sgRNA gene knockout kit (100)
Sign In for Pricing
View Details