Trimethoprim (Standard)

Trimethoprim (Standard) is the analytical standard of Trimethoprim. This product is intended for research and analytical applications. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc[1][2][3][4].

Product Specifications

CAS Number

[738-70-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Antifolate; Bacterial; Influenza Virus; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/trimethoprim-standard.html

Purity

99.98

Smiles

NC1=NC=C(CC2=CC(OC)=C(OC)C(OC)=C2)C(N)=N1

Molecular Formula

C14H18N4O3

Molecular Weight

290.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Laskowska, E., et al., Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47 (4) : p. 286-9.|[2]Brogden, R.N., et al., Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs, 1982. 23 (6) : p. 405-30.|[3]Xiaojian Wang, et al. A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjug Chem. 2018 May 16;29 (5) :1729-1735.|[4]El Habbal MH. Combination therapy of zinc and trimethoprim inhibits infection of influenza A virus in chick embryo. Virol J. 2021 Jun 3;18 (1) :113.