Penbutolol (sulfate)

Penbutolol sulfate ((-) -Terbuclomine) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3[1][2].

Product Specifications

CAS Number

[38363-32-5]

Product Name Alternative

(-) -Terbuclomine

UNSPSC

12352005

Hazard Statement

H302, H336

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Penbutolol-sulfate.html

Purity

98.72

Solubility

H2O : 1.67 mg/mL (ultrasonic)

Smiles

O[C@@H](CNC(C)(C)C)COC1=CC=CC=C1C2CCCC2.O=S(O)(O)=O

Molecular Formula

C18H29NO2.1/2H2SO4

Molecular Weight

340.47

Precautions

H302, H336

References & Citations

[1]Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-) penbutolol. J Pharmacol Exp Ther. 1993 May;265 (2) :707-12.|[2]M E Castro, et al. Affinity of (±) -Pindolol, (-) -Penbutolol, and (-) -Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762.|[3]Gartside SE, et al., Effects of (-) -tertatolol, (-) -penbutolol and (+/-) -pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. Br J Pharmacol. 1999 May;127 (1) :145-52.