AUNP-12 (TFA)

AUNP-12 TFA (NP-12 TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 TFA exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) [1].

Product Specifications

Product Name Alternative

NP-12 (TFA)

UNSPSC

12352209

Target

PD-1/PD-L1

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/np-12-tfa.html

Purity

98.03

Solubility

10 mM in DMSO

Smiles

OC(CC[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](CCCCN)NC([C@H]1N(CCC1)C([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCCNC([C@@H](NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)NC([C@@H](NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]

Molecular Formula

C142H226N40O48.xC2HF3O2

Molecular Weight

3261.60

References & Citations

[1]Sasikumar PG, et al. A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 2019 Jun;18 (6) :1081-1091.