LIX/CXCL5, Mouse

CXCL5, also known as neutrophil activating peptide 78 (ENA‐78), is a CXC chemokine containing ELR motif. CXCL5 promotes angiogenesis through interaction with its specific receptor CXCR2. CXCL5 is expressed by many immune cells, such as macrophages, eosinophils, and non-immune cells including mesothelial cells, and fibroblasts.CXCL5/CXCR2 axis not only contributes to the recruitment of neutrophils but also regulates the function of neutrophils in melanoma[1][2]. LIX/CXCL5 Protein, Mouse is produced in E.coil, and consists of 92 amino acids (A41-Q132) .

Product Specifications

Product Name Alternative

LIX/CXCL5 Protein, Mouse, Mouse, E. coli

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/lix-cxcl5-protein-mouse.html

Purity

97.00

Smiles

APSSVIAATELRCVCLTVTPKINPKLIANLEVIPAGPQCPTVEVIAKLKNQKEVCLDPEAPVIKKIIQKILGSDKKKAKRNALAVERTASVQ

Molecular Formula

20311 (Gene_ID) P50228 (A41-Q132) (Accession)

Molecular Weight

Approximately 9.8 kDa

References & Citations

[1]Kawamura M, et al. CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer. Eur J Cancer. 2012 Sep;48 (14) :2244-51.|[2]Wen Zhang, et al. CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target. Cancer Commun (Lond) . 2020 Mar;40 (2-3) :69-80.|[3]Chun Chen, et al. CXCL5 induces tumor angiogenesis via enhancing the expression of FOXD1 mediated by the AKT/NF-κB pathway in colorectal cancer. Cell Death Dis. 2019 Feb 21;10 (3) :178.|[4]Junjie Mei, et al. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity. 2010 Jul 23;33 (1) :106-17.|[5]Carine Chavey, et al. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab. 2009 Apr;9 (4) :339-49.