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Sabizabulin

VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC50 of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer[1][2][3].

Product Specifications

Product Name Alternative

VERU-111; ABI-231

UNSPSC

12352005

Target

Apoptosis; HPV; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/veru-111.html

Purity

99.00

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(C1=CNC(C2=CNC3=C2C=CC=C3)=N1)C4=CC(OC)=C(OC)C(OC)=C4

Molecular Formula

C21H19N3O4

Molecular Weight

377.39

References & Citations

[1]Wang Q, et al. Structure-Guided Design, Synthesis, and Biological Evaluation of (2- (1H-Indol-3-yl) -1H-imidazol-4-yl) (3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin. J Med Chem. 2019 Jul 12.|[2]Qinghui Wang, et al. Discovery of ABI-231 analogs targeting the colchicine site in tubulin for advanced melanoma. Cancer Research 76 (14 Supplement) :4848-4848.|[3]Vivek Kashyap, et al. ABI-231: A novel small molecule suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting Human papilloma virus (HPV) E6 and E7. Cancer Research 78 (13 Supplement) :679-679.|[4]Kashyap VK, et al. Therapeutic efficacy of a novel βIII/βIV-tubulin inhibitor (VERU-111) in pancreatic cancer. J Exp Clin Cancer Res. 2019 Jan 23;38 (1) :29.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-120599/Sabizabulin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-120599/Sabizabulin-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 3

CAS Number

[1332881-26-1]

Available Sizes

Curated Selection

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