Sabizabulin
VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC50 of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer[1][2][3].
Product Specifications
Product Name Alternative
VERU-111; ABI-231
UNSPSC
12352005
Target
Apoptosis; HPV; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/veru-111.html
Purity
99.00
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(C1=CNC(C2=CNC3=C2C=CC=C3)=N1)C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C21H19N3O4
Molecular Weight
377.39
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120599/Sabizabulin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120599/Sabizabulin-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Phase 3
CAS Number
[1332881-26-1]
Available Sizes
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