Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Sabizabulin

VERU-111 (ABI-231) is a potent and orally active α and β tubulin inhibitor, which displays strong antiproliferative activity, with an average IC50 of 5.2 nM against panels of melanoma and prostate cancer cell lines. VERU-111 (ABI-231) suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting HPV E6 and E7, and has potential for the treatment of prostate cancer[1][2][3].

Product Specifications

CAS Number

1332881-26-1

Product Name Alternative

VERU-111; ABI-231

UNSPSC

12352005

Target

Apoptosis; HPV; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/veru-111.html

Purity

99.00

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(C1=CNC(C2=CNC3=C2C=CC=C3)=N1)C4=CC(OC)=C(OC)C(OC)=C4

Molecular Formula

C21H19N3O4

Molecular Weight

377.39

References & Citations

[1]Wang Q, et al. Structure-Guided Design, Synthesis, and Biological Evaluation of (2- (1H-Indol-3-yl) -1H-imidazol-4-yl) (3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin. J Med Chem. 2019 Jul 12.|[2]Qinghui Wang, et al. Discovery of ABI-231 analogs targeting the colchicine site in tubulin for advanced melanoma. Cancer Research 76 (14 Supplement) :4848-4848.|[3]Vivek Kashyap, et al. ABI-231: A novel small molecule suppresses tumor growth and metastatic phenotypes of cervical cancer cells via targeting Human papilloma virus (HPV) E6 and E7. Cancer Research 78 (13 Supplement) :679-679.|[4]Kashyap VK, et al. Therapeutic efficacy of a novel βIII/βIV-tubulin inhibitor (VERU-111) in pancreatic cancer. J Exp Clin Cancer Res. 2019 Jan 23;38 (1) :29.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

N-Acetyl-2-amino-5-phenylpyridine
TRC-A168290-1G 1 g

N-Acetyl-2-amino-5-phenylpyridine

Sign In for Pricing
View Details
CD5 (CD5/54/F6), CF405S conjugate, 0.1mg/mL
BNC040746-500 1x 500 µL

CD5 (CD5/54/F6), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Elof1 (NM_170777) Mouse Tagged ORF Clone
MG200161 10 µg

Elof1 (NM_170777) Mouse Tagged ORF Clone

Sign In for Pricing
View Details
POMC Polyclonal Antibody
E-AB-15785-01 20 µL

POMC Polyclonal Antibody

Sign In for Pricing
View Details
POMC Polyclonal Antibody
E-AB-15785-02 60 µL

POMC Polyclonal Antibody

Sign In for Pricing
View Details
POMC Polyclonal Antibody
E-AB-15785-03 120 µL

POMC Polyclonal Antibody

Sign In for Pricing
View Details