4-Phenyl-1,2,3-thiadiazole

4-Phenyl-1,2,3-thiadiazole is an CYP2B4 and CYP2E1 inhibitor. 4-Phenyl-1,2,3-thiadiazole inhibits the oxidation of 1-phenylethanol to acetophenone by CYP2B4 and CYP2E1[1].

Product Specifications

CAS Number

[25445-77-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-phenyl-1-2-3-thiadiazole.html

Smiles

C1(C2=CC=CC=C2)=CSN=N1

Molecular Formula

C8H6N2S

Molecular Weight

162.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Babu BR, et al. 1,2,3-Thiadiazole: a novel heterocyclic heme ligand for the design of cytochrome P450 inhibitors. Biochemistry. 1997 Jun 10;36 (23) :7209-16.