Dextran sulfate sodium salt (MW 5000)

Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR) [1][2][3][4][5].

Product Specifications

CAS Number

[9011-18-1]

Product Name Alternative

DSS (MW 5000) ; DXS (MW 5000)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Complement System; HIV

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dextran-sulfate-sodium-salt-mw5000.html

Solubility

H2O : 50 mg/mL (ultrasonic)

Molecular Weight

5000 (Average)

Precautions

H302, H315, H319, H335

References & Citations

[1]Johansson H, et al. Low molecular weight dextran sulfate: a strong candidate drug to block IBMIR in clinical islet transplantation. Am J Transplant. 2006 Feb;6 (2) :305-12. |[2]Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85 (16) :6132-6.|[3]Araki Y, et al. Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis. Oncol Rep. 2012 Nov;28 (5) :1597-605. |[4]Laumonier T, et al. Low molecular weight dextran sulfate binds to human myoblasts and improves their survival after transplantation in mice. Cell Transplant. 2013;22 (7) :1213-26.|[5]Banz Y, et al. Dextran sulfate modulates MAP kinase signaling and reduces endothelial injury in a rat aortic clamping model. J Vasc Surg. 2009 Jul;50 (1) :161-70.