5-Amino-3H-imidazole-4-Carboxamide
5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular[1][2][3].
Product Specifications
CAS Number
[360-97-4]
Product Name Alternative
5-Aminoimidazole-4-carboxamide; AICA
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5-Amino-3H-imidazole-4-Carboxamide.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N)NC=N1)N
Molecular Formula
C4H6N4O
Molecular Weight
126.12
Precautions
H315, H319, H335
References & Citations
[1]YANG LIU. VARIABLE-TEMPERATURE 1 H-NMR AND AB INITIO STUDY OF 5-AMINO-IMIDAZOLE-4-CARBOXAMIDE (AICA) : COMPETING PATHS FOR AMIDE-H SCRAMBLING. DECEMBER 2008.|[2]Wojtaszewski JF, et al. Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA) -riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle. Diabetes. 2002 Feb;51 (2) :284-92.|[3]Sheldrick W S, et al. The structures of two tricyclic phosphoranes displaying facial placement of the fused bicyclic system[J]. Acta Crystallographica Section B: Structural Crystallography and Crystal Chemistry, 1980, 36 (10) : 2316-2323.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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