Human SETDB1 (recombinant)

<strong>Human SETDB1 (recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2016755_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 20 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 114 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> ERG-associated Protein With SET domain, ESET, Histone-lysine N-methyltransferase SETDB1, SET Domain Bifurcated 1, KMT1E_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Lin J, Guo D, Liu H, Zhou W, Wang C, Müller I, Kossenkov AV, Drapkin R, Bitler BG, Helin K, Zhang R. The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity Cancer Immunol Res. 2021 Dec;9(12):1413-1424._x000D_ 2: Tachibana K, Gotoh E, Kawamata N, Ishimoto K, Uchihara Y, Iwanari H, Sugiyama A, Kawamura T, Mochizuki Y, Tanaka T, Sakai J, Hamakubo T, Kodama T, Doi T. Analysis of the subcellular localization of the human histone methyltransferase SETDB1 Biochem Biophys Res Commun. 2015 Oct 2;465(4):725-31._x000D_ 3: Yoshikawa Y, Emi M, Nakano T, Gaudino G. Mesothelioma developing in carriers of inherited genetic mutations Transl Lung Cancer Res. 2020 Feb;9(Suppl 1):S67-S76._x000D_ 4: Gauchier M, Kan S, Barral A, Sauzet S, Agirre E, Bonnell E, Saksouk N, Barth TK, Ide S, Urbach S, Wellinger RJ, Luco RF, Imhof A, Déjardin J. SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres Sci Adv. 2019 May 8;5(5):eaav3673._x000D_ 5: Sun QY, Ding LW, Xiao JF, Chien W, Lim SL, Hattori N, Goodglick L, Chia D, Mah V, Alavi M, Kim SR, Doan NB, Said JW, Loh XY, Xu L, Liu LZ, Yang H, Hayano T, Shi S, Xie D, Lin DC, Koeffler HP. SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway J Pathol. 2015 Mar;235(4):559-70._x000D_ 6: Trush VV, Feller C, Li ASM, Allali-Hassani A, Szewczyk MM, Chau I, Eram MS, Jiang B, Luu R, Zhang F, Barsyte-Lovejoy D, Aebersold R, Arrowsmith CH, Vedadi M. Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro Biochim Biophys Acta Gene Regul Mech. 2022 Jul;1865(5):194845._x000D_ 7: Funyu T, Kanemaru Y, Onoda H, Arita K. Preparation of the ubiquitination-triggered active form of SETDB1 in Escherichia coli for biochemical and structural analyses J Biochem. 2021 Dec 28;170(5):655-662._x000D_ 8: Hirota T, Blakeley P, Sangrithi MN, Mahadevaiah SK, Encheva V, Snijders AP, ElInati E, Ojarikre OA, de Rooij DG, Niakan KK, Turner JMA. SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice Dev Cell. 2018 Dec 3;47(5):645-659.e6._x000D_ 9: Ngo AM, Puschnik AS. Genome-Scale Analysis of Cellular Restriction Factors That Inhibit Transgene Expression from Adeno-Associated Virus Vectors J Virol. 2023 Apr 27;97(4):e0194822._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/25715926">10: Song YJ, Choi JH, Lee H. Setdb1 is required for myogenic differentiation of C2C12 myoblast cells via maintenance of MyoD expression Mol Cells. 2015 Apr;38(4):362-72. </a>_x000D_ _x000D_ <strong>Products Related to Human SETDB1 (recombinant) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>