3-Bromopyruvic acid

3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK) -II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities[1][2][3].

Product Specifications

CAS Number

[1113-59-3]

Product Name Alternative

Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP

UNSPSC

12352211

Hazard Statement

H314

Target

Apoptosis; Autophagy; Hexokinase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3-Bromopyruvic-acid.html

Purity

99.44

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 175 mg/mL (ultrasonic)

Smiles

O=C(O)C(CBr)=O

Molecular Formula

C3H3BrO3

Molecular Weight

166.96

Precautions

H314

References & Citations

[1]Gan L, et al. Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy. Onco Targets Ther. 2020;13:11125-11137. Published 2020 Oct 29.|[2]Chen Y, et al. 3 Bromopyruvate sensitizes human breast cancer cells to TRAIL induced apoptosis via the phosphorylated AMPK mediated upregulation of DR5. Oncol Rep. 2018;40 (5) :2435-2444.|[3]Zhang Q, et al. Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells. Genes Cancer. 2014;5 (3-4) :100-112.