Nordihydrocapsaicin

Nordihydrocapsaicin, an analog of Capsaicin (HY-10448), is an orally active compound with pungent properties and anti-cancer activities, which is found in fresh and processed peppers. Nordihydrocapsaicin can cause a burning sensation when consumed[1][2][3][4].

Product Specifications

CAS Number

[28789-35-7]

UNSPSC

12352005

Hazard Statement

H300, H311, H315, H317, H318, H334, H335

Target

Keap1-Nrf2; NADPH Oxidase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nordihydrocapsaicin.html

Purity

99.82

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)CCCCCC(NCC1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C17H27NO3

Molecular Weight

293.40

Precautions

H300, H311, H315, H317, H318, H334, H335

References & Citations

[1]Alvarez-Parrilla E, et al. Antioxidant activity of fresh and processed Jalapeño and Serrano peppers. J Agric Food Chem. 2011 Jan 12;59 (1) :163-73.|[2]Şanlıer N, et al. The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight[J]. Clinical and Experimental Health Sciences, 2024, 14 (1) : 273-282.|[3]Sahin K, et al. Capsaicinoids improve consequences of physical activity. Toxicol Rep. 2018 May 15;5:598-607.|[4]Sahin K, et al. Ingested capsaicinoids can prevent low-fat-high-carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways. J Inflamm Res. 2017 Nov 13;10:161-168.