Tominersen
Tominersen (RG6042) is a second-generation 2′-O- (2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) [1][2].
Product Specifications
CAS Number
1709886-74-7
Product Name Alternative
RG6042; IONIS-HTTRx
UNSPSC
12352208
Target
Huntingtin
Type
Oligonucleotides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tominersen.html
Purity
97.34
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[Tominersen]
Molecular Formula
C230H319N74O122P19S13
Molecular Weight
7078.00
References & Citations
[1]Tabrizi SJ, et, al. Targeting Huntingtin Expression in Patients with Huntington's Disease. N Engl J Med. 2019 Jun 13;380 (24) :2307-2316.|[2]Kordasiewicz HB, et al. Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron. 2012 Jun 21;74 (6) :1031-44.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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