Tominersen

Tominersen (RG6042) is a second-generation 2′-O- (2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) [1][2].

Product Specifications

CAS Number

[1709886-74-7]

Product Name Alternative

RG6042; IONIS-HTTRx

UNSPSC

12352208

Target

Huntingtin

Type

Oligonucleotides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tominersen.html

Purity

97.34

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

[Tominersen]

Molecular Formula

C230H319N74O122P19S13

Molecular Weight

7078.00

References & Citations

[1]Tabrizi SJ, et, al. Targeting Huntingtin Expression in Patients with Huntington's Disease. N Engl J Med. 2019 Jun 13;380 (24) :2307-2316.|[2]Kordasiewicz HB, et al. Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron. 2012 Jun 21;74 (6) :1031-44.