Jatrorrhizine (hydroxide)
Product Specifications
UNSPSC Description
Jatrorrhizine?hydroxide is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities[1]. Jatrorrhizine hydroxide is a potent and orally active inhibitor of?AChE?(IC50=872 nM) over >115-fold selectivity for BuChE[2]. Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters[3].
Target Antigen
5-HT Receptor; Bacterial; Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Anti-infection;GPCR/G Protein;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jatrorrhizine-hydroxide.html
Purity
98.07
Solubility
DMSO : 3.33 mg/mL (ultrasonic)|H2O : 2.5 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[OH-]
Molecular Weight
355.38
References & Citations
[1]Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.|[2]Xiaofei Jiang, et al. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. Research Article Volume 2017|[3]C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0749A/Jatrorrhizine-hydroxide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0749A/Jatrorrhizine-hydroxide-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
483-43-2
Available Sizes
Curated Selection
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