Apoptosis inducer 22
Apoptosis inducer 22 (QR-5) is an apoptosis inducer with IC50 values of 63.1 and 46.5 μM for colon cancer cell lines SW480 and HT29, respectively. Apoptosis inducer 22 induces apoptosis by inhibiting the Wnt/β-catenin axis in colon cancer cells. Apoptosis inducer 22 can be used in anti-colon cancer research.
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Wnt
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apoptosis-inducer-22.html
Smiles
FC(F)(F)C1(CC1)C2=CC(NC(NC3=CC=CC(OC)=C3)=O)=NO2
Molecular Formula
C15H14F3N3O3
Molecular Weight
341.29
References & Citations
[1]Suresh, et al. "Isoxazolyl-urea derivative evokes apoptosis and paraptosis by abrogating the Wnt/β-catenin axis in colon cancer cells." Chemico-Biological Interactions 399 (2024) : 111143.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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