Apoptosis inducer 22

Apoptosis inducer 22 (QR-5) is an apoptosis inducer with IC50 values of 63.1 and 46.5 μM for colon cancer cell lines SW480 and HT29, respectively. Apoptosis inducer 22 induces apoptosis by inhibiting the Wnt/β-catenin axis in colon cancer cells. Apoptosis inducer 22 can be used in anti-colon cancer research.

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Wnt

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apoptosis-inducer-22.html

Smiles

FC(F)(F)C1(CC1)C2=CC(NC(NC3=CC=CC(OC)=C3)=O)=NO2

Molecular Formula

C15H14F3N3O3

Molecular Weight

341.29

References & Citations

[1]Suresh, et al. "Isoxazolyl-urea derivative evokes apoptosis and paraptosis by abrogating the Wnt/β-catenin axis in colon cancer cells." Chemico-Biological Interactions 399 (2024) : 111143.