Rivastigmine carbamate impurity

Rivastigmine carbamate impurity (3-Nitrophenyl ethyl (methyl) carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively[1][2].

Product Specifications

CAS Number

[1346242-31-6]

Product Name Alternative

3-Nitrophenyl ethyl (methyl) carbamate

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rivastigmine-carbamate-impurity.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC1=CC=CC([N+]([O-])=O)=C1)N(CC)C

Molecular Formula

C10H12N2O4

Molecular Weight

224.22

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Ziwei Chen, et al. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease. Eur J Med Chem. 2017 Jan 5;125:784-792.|[2]Qian-Sheng Yu, et al. Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem. 2002 Aug 15;45 (17) :3684-91.