DCDAPH

DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS) . DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM) . DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo[1].

Product Specifications

CAS Number

[125113-96-4]

UNSPSC

12171500

Target

Amyloid-β

Type

Dye Reagents

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dcdaph.html

Solubility

10 mM in DMSO

Smiles

CN(C1=CC=C(/C=C/C=C/C=C(C#N)/C#N)C=C1)C

Molecular Formula

C16H15N3

Molecular Weight

249.31

References & Citations

[1]Mengchao Cui, et al. Smart near-infrared fluorescence probes with donor-acceptor structure for in vivo detection of β-amyloid deposits. J Am Chem Soc. 2014 Mar 5;136 (9) :3388-94.