Thalidomide-NH-C10-COOH
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology[1].
Product Specifications
CAS Number
[2428400-33-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-nh-c10-cooh.html
Purity
97.50
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N(C1=O)C(C(N2)=O)CCC2=O)C3=C1C=CC=C3NCCCCCCCCCCC(O)=O
Molecular Formula
C24H31N3O6
Molecular Weight
457.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9 (1) :19654.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
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