KX1-004

KX1-004 is a potent and non-ATP competitive Src-PTK inhibitor with an IC50 of 40 μM. KX1-004 protects the cochlea from hazardous noise and prevents noise-induced hearing loss (NIHL) [1][2].

Product Specifications

CAS Number

[518058-84-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/KX1-004.html

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(N1)=CC2=C1C=CC(F)=C2)NCC3=CC=CC(O)=C3

Molecular Formula

C16H13FN2O2

Molecular Weight

284.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Harris KC, et al. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hear Res. 2005 Oct;208 (1-2) :14-25.|[2]Bielefeld EC, et al. A comparison of the protective effects of systemic administration of a pro-glutathione drug and a Src-PTK inhibitor against noise-induced hearing loss. Noise Health. 2005 Oct-Dec;7 (29) :24-30.