U-99194 (maleate)

U-99194 (PNU-99194) maleate is a selective, potent dopamine D3 receptor antagonist (Ki =160 nM) . U-99194 maleate inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 maleate abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 maleate significantly suppresses Nicotine (HY-127019) -induced tremor in mice. U-99194 maleate can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors[1][2].

Product Specifications

CAS Number

[234757-41-6]

Product Name Alternative

U-99194A; PNU-99194A (maleate) ; JPC-211 (maleate)

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/u-99194-maleate.html

Purity

99.23

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

CCCN(CCC)C1CC2=C(C=C(OC)C(OC)=C2)C1.O=C(O)/C=C\C(O)=O

Molecular Formula

C21H31NO6

Molecular Weight

393.47

References & Citations

[1]Kato M, et al. Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor. Front Pharmacol. 2022 Jun 16;13:938175. |[2]Hammad H, et al. Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation. J Pharmacol Exp Ther. 2006 Jan;316 (1) :113-20. |[3]Audinot V, et al. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+) -S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther. 1998 Oct;287 (1) :187-97.