NPD8790
NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths[1].
Product Specifications
CAS Number
[615281-26-0]
UNSPSC
12352005
Target
Mitochondrial Metabolism; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/npd8790.html
Smiles
CC(CC1=CC=C(C=C1)C(C2=NC3=C(N2C)C=CC=C3)C)C
Molecular Formula
C20H24N2
Molecular Weight
292.42
References & Citations
[1]Taylor Davie, et al. Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nat Commun. 2024 May 8;15 (1) :3367.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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