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AKR1C1 / AKR1C2 Recombinant Rabbit Monoclonal Antibody [JE33-84]

Aldo-keto reductase family 1 (AKR1) is a family of aldo-keto reductase enzymes that is involved in steroid metabolism. It includes the AKR1C and AKR1D subgroups, which respectively consist of AKR1C1–AKR1C4 and AKR1D1. Together with short-chain dehydrogenase/reductases (SDRs), these enzymes catalyze oxidoreductions, act on the C3, C5, C11, C17 and C20 positions of steroids, and function as 3α-HSDTooltip 3α-Hydroxysteroid dehydrogenases, 3β-HSDsTooltip 3β-Hydroxysteroid dehydrogenases, 5β-reductases, 11β-HSDsTooltip 11β-Hydroxysteroid dehydrogenases, 17β-HSDsTooltip 17β-hydroxysteroid dehydrogenases, and 20α-HSDsTooltip 20α-Hydroxysteroid dehydrogenases, respectively. The AKR1C enzymes act as 3-, 17- and 20-ketosteroid reductases, while AKR1D1 acts as the sole 5β-reductase in humans.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

20 alpha (3 alpha) hydroxysteroid dehydrogenase antibody 20-alpha-HSD antibody 20-alpha-hydroxysteroid dehydrogenase antibody 3-alpha-HSD3 antibody AKR1C1 antibody AKR1C2 antibody Aldo-keto reductase family 1 member C1 antibody Aldo-keto reductase family 1 member C2 antibody Chlordecone reductase homolog HAKRC antibody Chlordecone reductase homolog HAKRD antibody DD-2 antibody DD/BABP antibody DD1 antibody DD1/DD2 antibody DD2 antibody DDH antibody DDH1 antibody DDH2 antibody Dihydrodiol dehydrogenase 1 antibody Dihydrodiol dehydrogenase 1/2 antibody Dihydrodiol dehydrogenase 2 antibody dihydrodiol dehydrogenase isoform DD1 antibody Dihydrodiol dehydrogenase/bile acid-binding protein antibody HBAB antibody Hepatic dihydrodial dehydrogenase antibody High-affinity hepatic bile acid-binding protein antibody Indanol dehydrogenase antibody MBAB antibody MGC8954 antibody Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase antibody Type III 3-alpha-hydroxysteroid dehydrogenase antibody

Abbreviation

AKR1C1, DDH, DDH1, AKR1C2, DDH2

Swiss Prot

Q04828 Human, P52895 Human

Cellular Locus

Cytoplasm, cytosol.

Host

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Recombinant protein within

Isotype

IgG

Clone

JE33-84

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

HeLa cell lysate, HepG2 cell lysate, Human liver tissue lysate, Mouse liver tissue lysate, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 37 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes

Frequently Asked Questions

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