Fas Ligand, Rat (P.pastoris, His)

Fas Ligand (CD178; APTL) is a ligand to TNFRSF6/FAS/CD95, transduces the apoptotic signal to regulate cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development[1]. Rat Fas Ligand exhibits 4 isoforms, the soluble form (127-278 a.a.) involves in germ cell apoptosis in testis of rats undergoing autoimmune orchitis[4]. Fas Ligand Protein, Rat (P.pastoris, His) has a total length of 175 amino acids (L104-L278), is expressed in P.pastoris cells with N-terminal His-tag.

[1]Schneider P, et al. Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. J Biol Chem. 1997 Jul 25;272(30):18827-33.|[2]Liu W, et al. Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. Structure. 2016 Nov 1;24(11):2016-2023.|[3]Martínez-Lorenzo MJ, et al. Release of preformed Fas ligand in soluble form is the major factor for activation-induced death of Jurkat T cells. Immunology. 1996 Dec;89(4):511-7.|[4]Jacobo PV, et al. Involvement of soluble Fas Ligand in germ cell apoptosis in testis of rats undergoing autoimmune orchitis. Cytokine. 2012 Nov;60(2):385-92.|[5]Puppo F, et al. Fas, Fas ligand, and transfusion immunomodulation. Transfusion. 2001 Mar;41(3):416-8.