Genz-644282
Product Specifications
UNSPSC Description
Genz-644282 is a non-camptothecin topoisomerase I inhibitor, used for cancer research.
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Genz-644282.html
Solubility
DMSO : 3.64 mg/mL (ultrasonic;warming;heat to 75°C)
Smiles
O=C1N(CCNC)C2=C(C=NC(C2=C3)=CC4=C3OCO4)C5=CC(OC)=C(OC)C=C15
Molecular Weight
407.42
References & Citations
[1]Kurtzberg LS, et al. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17(9):2777-87.|[2]Houghton PJ, et al. Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Feb;58(2):200-9.|[3]Sooryakumar D, et al. Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10(8):1490-9.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16228/Genz-644282-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16228/Genz-644282-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
529488-28-6
Available Sizes
Curated Selection
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