Genz-644282
Genz-644282 is a non-camptothecin topoisomerase I inhibitor, used for cancer research.
Product Specifications
CAS Number
529488-28-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Genz-644282.html
Purity
99.13
Solubility
DMSO : 3.64 mg/mL (ultrasonic; warming; heat to 75°C)
Smiles
O=C1N(CCNC)C2=C(C=NC(C2=C3)=CC4=C3OCO4)C5=CC(OC)=C(OC)C=C15
Molecular Formula
C22H21N3O5
Molecular Weight
407.42
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kurtzberg LS, et al. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17 (9) :2777-87.|[2]Houghton PJ, et al. Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Feb;58 (2) :200-9.|[3]Sooryakumar D, et al. Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10 (8) :1490-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Topo I
Available Sizes
Frequently Asked Questions
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