Genz-644282

Genz-644282 is a non-camptothecin topoisomerase I inhibitor, used for cancer research.

Product Specifications

CAS Number

[529488-28-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Genz-644282.html

Purity

99.13

Solubility

DMSO : 3.64 mg/mL (ultrasonic; warming; heat to 75°C)

Smiles

O=C1N(CCNC)C2=C(C=NC(C2=C3)=CC4=C3OCO4)C5=CC(OC)=C(OC)C=C15

Molecular Formula

C22H21N3O5

Molecular Weight

407.42

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kurtzberg LS, et al. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17 (9) :2777-87.|[2]Houghton PJ, et al. Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Feb;58 (2) :200-9.|[3]Sooryakumar D, et al. Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10 (8) :1490-9.