Recombinant Human Lck Protein (Full Length, GST Tag, Active)

<strong>Recombinant Human Lck Protein (Full Length, GST Tag, Active)</strong>_x000D_ <strong>Catalog number:</strong> B2019016_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> ~84 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −80°C_x000D_ <strong>Keywords:</strong> IMD22 Protein, Human; LCK Protein, Human; LSK Protein, Human; p56lck Protein, Human; pp58lck Protein, Human; YT16 Protein, Human_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Zhou J, Blevins LK, Crawford RB, Kaminski NE. Role of Programmed Cell Death Protein-1 and Lymphocyte Specific Protein Tyrosine Kinase in the Aryl Hydrocarbon Receptor- Mediated Impairment of the IgM Response in Human CD5(+) Innate-Like B Cells Front Immunol. 2022 Apr 26;13:884203._x000D_ 2: Antón O, Batista A, Millán J, Andrés-Delgado L, Puertollano R, Correas I, Alonso MA. An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes J Exp Med. 2008 Dec 22;205(13):3201-13._x000D_ 3: Pathan NI, Geahlen RL, Harrison ML. The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2 J Biol Chem. 1996 Nov 1;271(44):27517-23._x000D_ 4: Wright DD, Sefton BM, Kamps MP. Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia Mol Cell Biol. 1994 Apr;14(4):2429-37._x000D_ 5: Greenway A, Azad A, Mills J, McPhee D. Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity J Virol. 1996 Oct;70(10):6701-8._x000D_ 6: Hu XX, Zhang AJ, Pan WW, Xin QL, Chen JY, Zhang LL, Chang Y, Wu YJ, Wei W. An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis Acta Pharmacol Sin. 2022 Feb;43(2):387-400._x000D_ 7: Jullien P, Bougeret C, Camoin L, Bodeus M, Durand H, Disanto JP, Fischer S, Benarous R. Tyr394 and Tyr505 are autophosphorylated in recombinant Lck protein-tyrosine kinase expressed in Escherichia coli Eur J Biochem. 1994 Sep 1;224(2):589-96._x000D_ 8: Dutartre H, Harris M, Olive D, Collette Y. The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism Virology. 1998 Aug 1;247(2):200-11._x000D_ 9: Torigoe T, Millan JA, Chan KW, Taichman R, Brian AA, Reed JC, Tachman R [corrected to Taichman R]. Protein tyrosine kinase p56-Lck regulates lymphocyte function-associated 1 adhesion molecule expression, granule exocytosis, and cytolytic effector function in a cloned T cell J Exp Med. 1994 Sep 1;180(3):1115-27._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/17005671">10: Heck E, Friedrich U, Gack MU, Lengenfelder D, Schmidt M, Müller-Fleckenstein I, Fleckenstein B, Ensser A, Biesinger B. Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs J Virol. 2006 Oct;80(20):9934-42. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant Human Lck Protein (Full Length, GST Tag, Active) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>