Cbl-b-IN-16
Cbl-b-IN-16 (compound 31) is an orally active Cbl-b inhibtor with IC50 of 30 nM and induces IL-2 production in Hu-T-cells with EC50 of 230 nM. Cbl-b-IN-16 exhibits antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbl-b-in-16.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C2=CC=CC([C@@]3(C4=NN=CN4C)C[C@H](C)C3)=C2)=CC(C(F)(F)F)=CN1[C@H](C5=CN(C)N=C5)C
Molecular Formula
C26H27F3N6O
Molecular Weight
496.53
References & Citations
[1]Mfuh AM, et al., Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. J Med Chem. 2024 Jan 25;67 (2) :1500-1512.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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