P62-mediated mitophagy inducer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential[1].
Product Specifications
CAS Number
[1809031-84-2]
Product Name Alternative
TAK-013,CP 526555-15N3 (Hydrochloride),CP 526555-18
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Mitophagy; Mitosis; p62
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p62-mediated-mitophagy-inducer.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC(C2=CN(C3=CC=CC(I)=C3)N=N2)=CC=C1)[O-]
Molecular Formula
C14H9IN4O2
Molecular Weight
392.15
Precautions
H302, H315, H319, H335
References & Citations
[1]East DA, et al. PMI: a ΔΨm independent pharmacological regulator of mitophagy. Chem Biol. 2014 Nov 20;21 (11) :1585-96.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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