N-Desmethyl Sildenafil

N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2].

Product Specifications

CAS Number

[139755-82-1]

Product Name Alternative

Desmethylsildenafil; UK-103,320

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/n-desmethyl-sildenafil.html

Purity

99.53

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CCOC1=C(C=C(S(N2CCNCC2)(=O)=O)C=C1)C3=NC4=C(C(N3)=O)N(C)N=C4CCC

Molecular Formula

C21H28N6O4S

Molecular Weight

460.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Péter Barabás, et al. Sildenafil, N-desmethyl-sildenafil and Zaprinast enhance photoreceptor response in the isolated rat retina. Neurochem Int. 2003 Nov;43 (6) :591-5.|[2]Rikako Takahiro, et al. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38 (1) :58-65.