SZL P1-41

SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[1][2].

Product Specifications

CAS Number

[222716-34-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SZL-P1-41.html

Purity

99.07

Solubility

DMSO : 2.5 mg/mL (ultrasonic)

Smiles

O=C1C(C2=NC3=CC=CC=C3S2)=COC4=C(CN5CCCCC5)C(O)=C(CC)C=C14

Molecular Formula

C24H24N2O3S

Molecular Weight

420.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Chan CH et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154 (3) :556-68.|[2]Chan CH, et al. Skp2: a dream target in the coming age of cancer therapy. Cell Cycle. 2014;13 (5) :679-80.