Necrostatin 2 (racemate)
Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect[1].
Product Specifications
CAS Number
[852391-15-2]
Product Name Alternative
Necrostatin 1S; Nec-1S; 7-Cl-O-Nec1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/necrostatin-2-racemate.html
Concentration
10mM
Purity
99.51
Solubility
DMSO : ≥ 50 mg/mL
Smiles
ClC1=C2C(C(CC3C(N(C)C(N3)=O)=O)=CN2)=CC=C1
Molecular Formula
C13H12ClN3O2
Molecular Weight
277.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Takahashi N, et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis. 2012 Nov 29;3:e437.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2065296-01 0.1 mL
Cy3-Linked Polyclonal Antibody to Charcot Leyden Crystal Protein (CLC)
Ask
View Details