NLRP3-IN-40

NLRP3-IN-40 (compound 32) is an inhibitor of the inflammasome NLRP3, which blocks NLRP3 activation induced by multiple agonists without altering NLRC4 or AIM2 inflammasomes[1].

Product Specifications

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nlrp3-in-40.html

Smiles

C=C1[C@H]2C(O)[C@]3(C1=O)[C@@]4(OCCC(O)=O)[C@@H](O)[C@]5([H])C(C)(C)CC=C[C@@]5(CO4)[C@]3([H])CC2

Molecular Formula

C23H30O7

Molecular Weight

418.48

References & Citations

[1]He C, et al. Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity. J Med Chem. 2024 Jun 13;67 (11) :9406-9430.