NLRP3-IN-40
Product Specifications
UNSPSC Description
NLRP3-IN-40 (compound 32) is an inhibitor of the inflammasome NLRP3, which blocks NLRP3 activation induced by multiple agonists without altering NLRC4 or AIM2 inflammasomes[1].
Target Antigen
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-40.html
Smiles
C=C1[C@H]2C(O)[C@]3(C1=O)[C@@]4(OCCC(O)=O)[C@@H](O)[C@]5([H])C(C)(C)CC=C[C@@]5(CO4)[C@]3([H])CC2
Molecular Weight
418.48
References & Citations
[1]He C, et al. Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity. J Med Chem. 2024 Jun 13;67(11):9406-9430.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161669/NLRP3-IN-40-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161669/
Clinical Information
No Development Reported
Curated Selection
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