NLRP3-IN-40
NLRP3-IN-40 (compound 32) is an inhibitor of the inflammasome NLRP3, which blocks NLRP3 activation induced by multiple agonists without altering NLRC4 or AIM2 inflammasomes[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-40.html
Smiles
C=C1[C@H]2C(O)[C@]3(C1=O)[C@@]4(OCCC(O)=O)[C@@H](O)[C@]5([H])C(C)(C)CC=C[C@@]5(CO4)[C@]3([H])CC2
Molecular Formula
C23H30O7
Molecular Weight
418.48
References & Citations
[1]He C, et al. Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity. J Med Chem. 2024 Jun 13;67 (11) :9406-9430.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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