Pantothenate kinase-IN-2

Pantothenate kinase-IN-2 is a potent Pantothenate kinase 1/3 (PanK1/3) inhibitor with an IC50 of 0.14 μM and 0.36 μM. Pantothenate kinase-IN-2 is a promising agent for PKAN (PanK-associated neurodegeneration) and diabetes research[1].

Product Specifications

CAS Number

[902614-04-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

PANK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pantothenate-kinase-in-2.html

Concentration

10mM

Purity

98.18

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(SC)=C1)CCC2=C(C)N3C(N=C2C)=C(C=CC=N4)C4=N3

Molecular Formula

C21H21N5OS

Molecular Weight

391.49

Precautions

H315, H319, H335

References & Citations

[1]Lalit Kumar Sharma, et al. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J Med Chem. 2015 Feb 12;58 (3) :1563-8.