Pantothenate kinase-IN-2
Pantothenate kinase-IN-2 is a potent Pantothenate kinase 1/3 (PanK1/3) inhibitor with an IC50 of 0.14 μM and 0.36 μM. Pantothenate kinase-IN-2 is a promising agent for PKAN (PanK-associated neurodegeneration) and diabetes research[1].
Product Specifications
CAS Number
[902614-04-4]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
PANK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pantothenate-kinase-in-2.html
Concentration
10mM
Purity
98.18
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(SC)=C1)CCC2=C(C)N3C(N=C2C)=C(C=CC=N4)C4=N3
Molecular Formula
C21H21N5OS
Molecular Weight
391.49
Precautions
H315, H319, H335
References & Citations
[1]Lalit Kumar Sharma, et al. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J Med Chem. 2015 Feb 12;58 (3) :1563-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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