NLRP3-IN-46
NLRP3-IN-46 (Compound 3k) activates neuro-immunomodulatory cholinergic anti-inflammatory pathway, and thus inhibits NLRP3 inflammasome activation. NLRP3-IN-46 inhibits Uric acid sodium -induced IL-1β production in THP-1 cells, and can be used in gouty arthritis research[1].
Product Specifications
UNSPSC
12352101
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-46.html
Smiles
BrC1=CC=CC=C1OC2=NC(C[C@H]3[C@](C=C)([H])[C@]4(N(C)C)CC(C)=C3)=C4C=C2
Molecular Formula
C23H25BrN2O
Molecular Weight
425.36
References & Citations
[1]Wu HR, et al., Identification of O-arylated huperzinines as novel cholinergic anti-inflammatory pathway agonists against gout arthritis. Bioorg Chem. 2024 Nov;152:107716.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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