UU-T02

UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2].

Product Specifications

CAS Number

[1500080-17-0]

UNSPSC

12352005

Target

Wnt; β-catenin

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/uu-t02.html

Purity

99.63

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC(CC[C@@H](C(OC)=O)NC([C@H](CC(O)=O)NC([C@H](CC1=CC2=C(C=CC=C2)C=C1)NC(CC3=CC4=CC(Cl)=CC=C4N3)=O)=O)=O)=O

Molecular Formula

C33H33ClN4O9

Molecular Weight

665.09

References & Citations

[1]Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9 (1) :193-201.|[2]Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58 (11) :4678-4692.