UU-T02
Product Specifications
UNSPSC Description
UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2].
Target Antigen
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/uu-t02.html
Purity
99.63
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC(CC[C@@H](C(OC)=O)NC([C@H](CC(O)=O)NC([C@H](CC1=CC2=C(C=CC=C2)C=C1)NC(CC3=CC4=CC(Cl)=CC=C4N3)=O)=O)=O)=O
Molecular Weight
665.09
References & Citations
[1]Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9(1):193-201.|[2]Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117233/UU-T02-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117233/UU-T02-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1500080-17-0
Available Sizes
Curated Selection
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