Fitusiran (sodium)

Fitusiran sodium, an small interfering RNA, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran sodium increases thrombin generation and has the potential for the research of the hemophilia[1].

Product Specifications

Product Name Alternative

ALN-AT3SC (sodium) ; SAR439774 (sodium)

UNSPSC

12352208

Target

Factor Xa; Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fitusiran-sodium.html

Purity

95.08

Solubility

10 mM in H2O

Smiles

[Fitusiran(sodium)]

Molecular Formula

C520H635F21N175Na44O309P43S6

Molecular Weight

16248 (free acid)

References & Citations

[1]Pasi KJ, et al. Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran-Results of the phase 1 inhibitor cohort. J Thromb Haemost. 2021;19 (6) :1436-1446.