Aurora kinase-IN-3
Aurora kinase-IN-3 (Compound 15a) is an orally active AURKB inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB, rather than inhibiting its phosphorylation of H3 at Ser10[1].
Product Specifications
CAS Number
2840558-83-8
UNSPSC
12352005
Target
Aurora Kinase; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aurora-kinases-in-3.html
Purity
98.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CNC(C1=CC(OC(F)(F)F)=CC(OC2=C(C=CC=N2)C3=CC(OC)=NC=C3)=C1)=O
Molecular Formula
C20H16F3N3O4
Molecular Weight
419.35
References & Citations
[1]Lv G, et al. 2-Phenoxy-3, 4'-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114904.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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