MC-Gly-Gly-Phe-Gly- (R) -Cyclopropane-Exatecan

MC-Gly-Gly-Phe-Gly- (R) -Cyclopropane-Exatecan (SHR-A1811 Drug-linker) is a agent-linker conjugates for ADC, consisting Exatecan (HY-13631) . Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM) [1].

Product Specifications

CAS Number

[2414254-51-4]

Product Name Alternative

SHR-A1811 Drug-linker

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc-gly-gly-phe-gly-r-cyclopropane-exatecan.html

Purity

97.37

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCO[C@H](C3CC3)C(N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95)=O)=O)=O)=O)=O)=O

Molecular Formula

C55H60FN9O13

Molecular Weight

1074.12

References & Citations

[1]Ying Hua, et al. Anti-B7H3 antibody-exatecan analog conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020063673[P]. 2020-04-02.