2,2'-Anhydrouridine

2,2'-Anhydrouridine (2,2'-Cyclouridine) is a nucleoside analog. 2,2'-Anhydrouridine is an important intermediate in the synthesis of other nucleoside-related compounds[1][2].

Product Specifications

CAS Number

[3736-77-4]

Product Name Alternative

2,2'-Cyclouridine; O2,2'-Cyclouridine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2,2_acute_-Anhydrouridine.html

Purity

99.66

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC[C@@H](O1)[C@@H](O)[C@@](O2)([H])[C@]1([H])N(C2=N3)C=CC3=O

Molecular Formula

C9H10N2O5

Molecular Weight

226.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Drabikowska AK, et al. Inhibitor properties of some 5-substituted uracil acyclonucleosides, and 2,2'-anhydrouridines versus uridine phosphorylase from E. coli and mammalian sources. Biochem Pharmacol. 1987 Dec 1;36 (23) :4125-8.|[2]Mercer J R, et al. An improved synthesis of 14C-labelled 2, 2′-anhydrouridine, 2′-deoxyuridine and 5-ethyl-2′-deoxyuridine[J]. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1986, 37 (7) : 613-619.