Bevantolol (hydrochloride)

Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist[1][2].

Product Specifications

CAS Number

[42864-78-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Adrenergic Receptor; Calcium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bevantolol-hydrochloride.html

Purity

98.98

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 4.55 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(CNCCC1=CC=C(C(OC)=C1)OC)COC2=CC=CC(C)=C2.[H]Cl

Molecular Formula

C20H28ClNO4

Molecular Weight

381.89

Precautions

H302

References & Citations

[1]Takahiro Horinouchi, et al. Different Changes of Plasma Membrane Beta-Adrenoceptors in Rat Heart After Chronic Administration of Propranolol, Atenolol and Bevantolol. Life Sci. 2007 Jul 12;81 (5) :399-404.|[2]M Takita, et al. Selectivity of Bevantolol Hydrochloride Towards Alpha- And Beta-Adrenoceptor Subtypes in Rat Cerebral Cortex. Jpn J Pharmacol. 1992 Feb;58 (2) :193-6.