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Palmitoylglycine

Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].

Product Specifications

CAS Number

[2441-41-0]

Product Name Alternative

N-palmitoyl glycine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/palmitoylglycine.html

Purity

99.84

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)CNC(CCCCCCCCCCCCCCC)=O

Molecular Formula

C18H35NO3

Molecular Weight

313.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Neta Rimmerman, et al. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Mol Pharmacol. 2008 Jul;74 (1) :213-24.|[2]Xu H, et al. N-Palmitoyl glycine activates transient receptor potential channel 5 and increases the risk of Brugada syndrome[J]. medRxiv, 2024: 2024.10. 21.24315897.|[3]Bradshaw HB, et al. Novel endogenous N-acyl glycines identification and characterization. Vitam Horm. 2009;81:191-205.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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