Adenosine 5'-monophosphate (disodium)

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3].

Product Specifications

CAS Number

[4578-31-8]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/adenosine-5-monophosphate-disodium.html

Purity

99.92

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O[Na])(O[Na])=O

Molecular Formula

C10H12N5Na2O7P

Molecular Weight

391.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Ardiansyah, et al. Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet. BMC Complement Altern Med. 2018 Nov 14;18 (1) :304. |[2]Steven J. Swoap, et al. AMP does not induce torpor. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007 293:1, R468-R473. |[3]Holien JK, et al. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 Jan 15;28 (2) :202-206.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Isoform

Adenosine A2B receptor (A2BR)

Citation 01

J Exp Med. 2026 Jan 5;223 (1) :e20250440.|Anal Chem. 2025 May 13;97 (18) :9827-9835.|Biochem Biophys Res Commun. 2024 May 14:708:149814.|Cell. 2025 Oct 30;188 (22) :6151-6169.e24.|Genes (Basel) . 2022 Dec 16;13 (12) :2384.|Mar Pollut Bull. 2025 Nov:220:118455.|MedComm (2020) . 2025 Jan 8;6 (1) :e70046.|Molecules. 2023 Apr 11;28 (8) :3375.|Molecules. 2025 Mar 9;30 (6) :1224.|Nature. 2025 Jul;643 (8070) :192-200.|Research Square Preprint. 2022 May.|Stem Cell Res Ther. 2023 Sep 29;14 (1) :277.|Stem Cell Res Ther. 2025 Jun 2;16 (1) :277.|Stem Cell Res Ther. 2025 Mar 26;16 (1) :148.|Theranostics. 2020 Aug 13;10 (22) :10245-10261. |Theranostics. 2024 Aug 12;14 (12) :4874-4893.|University of Cambridge. 2023 Feb.