What is the catalog number for Myricanol?

The catalog number for Myricanol is HY-N3225.

What sizes are available for Myricanol?

Myricanol is available in the following size(s): 1 mg, 5 mg, 10 mg.

How many pack sizes does Myricanol come in?

Myricanol is available in 3 different pack sizes.

Is Myricanol in stock?

Myricanol is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Myricanol?

Myricanol is manufactured by QuantiMol.

What is the estimated delivery time for Myricanol?

Estimated delivery time for Myricanol is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Myricanol?

The safety data sheet for Myricanol is available here: http://file.medchemexpress.com/batch_PDF/HY-N3225/Myricanol-SDS-MedChemExpress.pdf.

Myricanol

Myricanol is a diarylheptanoid and a Nampt activator. Myricanol exerts anti-inflammatory effects and alleviates glucocorticoid-induced muscle atrophy by increasing Sirtuin 1 (SIRT1) and PRDX5 activities while regulating inflammatory factors. Myricanol exhibits growth inhibition and induces apoptosis in human lung adenocarcinoma A549 cells. Myricanol promotes autophagy-mediated clearance of microtubule-associated protein tau to exert neuroprotective effects. Myricanol protects cardiovascular function by inhibiting PDGFRβ and NF-κB signaling pathways. Myricanol activates mitochondrial transcription factor A (TFAM) expression to exert anti-renal fibrosis effects. Myricanol improves insulin resistance through AMPK activation[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

33606-81-4

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

AMPK; Apoptosis; Autophagy; Microtubule/Tubulin; NAMPT; NF-κB; PDGFR; Sirtuin

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/myricanol.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

COC1=C(C=C(CCCC[C@H]2O)C(O)=C1OC)C(C=C(CC2)C=C3)=C3O

Molecular Formula

C21H26O5

Molecular Weight

358.43

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Martin MD, et al. Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance. ACS Chem Biol. 2015;10 (4) :1099-1109.|[2]Shen S, et al. Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism. J Cachexia Sarcopenia Muscle. 2019 Apr;10 (2) :429-444.|[3]Shen S, et al. Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance. Br J Pharmacol. 2019 Oct;176 (20) :3983-4001. |[4]Zheng M, et al. Myricanol represses renal fibrosis by activating TFAM and ZNRF1 to inhibit tubular epithelial cells ferroptosis. Eur J Pharmacol. 2024 Dec 5;984:176999.|[5]Shen S, et al. Myricanol prevents aging-related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5. MedComm (2020) . 2024 Jun 12;5 (6) :e566.|[6]Fan S, et al. Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling. Front Physiol. 2022 Feb 3;12:790345.|[7]Lyu P, et al. Affinity-based protein profiling-driven discovery of myricanol as a Nampt activator. Bioorg Chem. 2023 Apr;133:106435.|[8]Dai GH, et al. Growth-inhibiting and apoptosis-inducing activities of Myricanol from the bark of Myrica rubra in human lung adenocarcinoma A549 cells. Phytomedicine. 2014 Sep 25;21 (11) :1490-6.