F3226-1387
F3226-1387 is a potent Entamoeba histolytica O-acetylserine sulfhydrylase EhOASS3 inhibitor with an IC50 value of 38 μM. F3226-1387 can suppress the growth of the amoeba[1].
Product Specifications
CAS Number
618877-25-1
UNSPSC
12352005
Target
Endogenous Metabolite; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/f3226-1387.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=NOC(C)=C2)C(C3=CC=CC(Cl)=C3)C(C(C4=CC5=CC=CC=C5O4)=O)=C1O
Molecular Formula
C23H15ClN2O5
Molecular Weight
434.83
References & Citations
[1]Dharavath S, et al. Crystal structure of O-Acetylserine sulfhydralase (OASS) isoform 3 from Entamoeba histolytica: Pharmacophore-based virtual screening and validation of novel inhibitors. Eur J Med Chem. 2020 Apr 15;192:112157.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Amebae
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