4-IBP

4-IBP is a selective σ₁ receptor agonist with high affinity for the σ₁ receptor (Ki =1.7 nM) and moderate affinity for the σ₂ receptor (Ki = 25.2 nM) . 4-IBP can make cancer cells more sensitive to the cytotoxic effects of pro-apoptotic and pro-autophagic compounds. 4-IBP significantly reduces the migration ability of a variety of cancer cells. 4-IBP is mainly used in glioblastoma, non-small cell lung cancer and prostate cancer research[1][2][3][4][5][6].

Product Specifications

CAS Number

[155798-08-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Sigma Receptor

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-IBP.html

Concentration

10mM

Purity

98.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC=C(I)C=C3

Molecular Formula

C19H21IN2O

Molecular Weight

420.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2007 May;9 (5) :358-69.|[2]Bermack JE, et al. Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands. Br J Pharmacol. 2001 Oct;134 (3) :691-9.|[3]Debeir O, et al. Videomicroscopic extraction of specific information on cell proliferation and migration in vitro. Exp Cell Res. 2008 Oct 1;314 (16) :2985-98.|[4]Amer MS, et al. Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol. 2013 Mar;168 (6) :1445-55.|[5]Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2007 May;9 (5) :358-69. |[6]Liu X, et al. Influence of Trishomocubanes on Sigma Receptor Binding of N- (1-Benzylpiperidin-4-yl) -4-[123I] iodobenzamide In Vivo in the Rat Brain. Medicinal Chemistry, 2005, 1 (1) : 31-38.