Adiphenine (hydrochloride)

Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine hydrochloride has anticonvulsant effects[1][2][3].

Product Specifications

CAS Number

[50-42-0]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Adiphenine-hydrochloride.html

Concentration

10mM

Purity

99.14

Solubility

DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL

Smiles

O=C(OCCN(CC)CC)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Molecular Formula

C20H26ClNO2

Molecular Weight

347.88

Precautions

H302, H312, H332

References & Citations

[1]Spitzmaul, G., et al., The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. Br J Pharmacol, 2009. 157 (5) : p. 804-17.|[2]Michelot, J., et al., Adiphenine plasma levels and blood-brain barrier crossing in the rat. Eur J Drug Metab Pharmacokinet, 1985. 10 (4) : p. 273-8.|[3]Gentry CL, et, al. Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299 (3) :1038-48.|[4]TANAKA K, et, al. Anticonvulsant properties of procaine, cocaine, adiphenine and related structures. Proc Soc Exp Biol Med. 1955 Oct;90 (1) :192-5.