Adiphenine (hydrochloride)
Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine hydrochloride has anticonvulsant effects[1][2][3].
Product Specifications
CAS Number
50-42-0
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Adiphenine-hydrochloride.html
Concentration
10mM
Purity
99.14
Solubility
DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL
Smiles
O=C(OCCN(CC)CC)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl
Molecular Formula
C20H26ClNO2
Molecular Weight
347.88
Precautions
H302, H312, H332
References & Citations
[1]Spitzmaul, G., et al., The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. Br J Pharmacol, 2009. 157 (5) : p. 804-17.|[2]Michelot, J., et al., Adiphenine plasma levels and blood-brain barrier crossing in the rat. Eur J Drug Metab Pharmacokinet, 1985. 10 (4) : p. 273-8.|[3]Gentry CL, et, al. Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299 (3) :1038-48.|[4]TANAKA K, et, al. Anticonvulsant properties of procaine, cocaine, adiphenine and related structures. Proc Soc Exp Biol Med. 1955 Oct;90 (1) :192-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
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Available Sizes
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